I’ve had three miscarriages and the last showed a large blood clot outside the pregnancy sac at 10 weeks. I never get ill – even if everyone aorund me has colds and coughs, I’m always fine. Do you think it’s possible I have an overactive immune system?

Submitted by smith on Mon, 03/02/2009 – 12:35.

Same thing happened to me. I went to reproductive endocrinologist to find out what the deal is. He said a blood clot can be because of a clotting disorder. I had several simple blood test and am waiting the results. What he did find thus far was a septated uterus, on a test called SHG. This can be the reason for nonimplantation, miscarriage or just not making it to full term. I got the septate repaired surgically during a histroscope. They go in through the vagina. Although for some septated uterous they have to go in through the belly button. Mine was not that kind. Good luck and keep a positive attitude. Login to post comments Up to a third of miscarriages Submitted by Angie on Thu, 03/05/2009 – 07:51. Up to a third of miscarriages are caused by an overactive immune system, so it is a possibility. Everyone has circulating in their body something called natural killer (NK) cells. They secrete a substance called TNF (tumor necrosis factor) and the overactivity of these cells producing their TNF – can be deadly to a pregnancy. Some women have over-active immune systems, causing the body to reject the implanted embryo. A possible treatment is called IVIG – intravenous immunoglobulin – and involves transfusions of blood products containing antibodies which suppress the faulty immune system. The drug is called Gammamune and it is administered through an IV over a period of three days each month (preconception). The treatment is controversial, with some experts still regarding it as experimental. A new clinical study shows that a steroid treatment may be beneficial for women suffering from multiple miscarriages. In the preliminary trials of the steroid – Prednisolone, 30 of the 40 women suffering from repeated miscarriages, all with high NK levels, went on to have successful pregnancies. So, talk to a fertility specialist about potential treatments before getting pregnant again.

Best wishes, Angie

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