Clinical Trials for Fertility Treatment, pt 1

Submitted by Angie Tue 03/16/2010

We have talked about the possibility of getting affordable treatments and one of the ways I haven’t talked about is participating in a clinical trial. Some are only for local residents, while others will pay for transportation and lodging as well. Most importantly, you are generally receiving some form of medical evaluation and perhaps treatment at a very reduced cost, or for free. Look for clinical trials in your area of interest at www.ClinicalTrials.gov. You may even get reimbursed for your time. These trials are currently enrolling: PCOS and Ovulation The purpose of this study is to bring about ovulation in women with infertility due to polycystic ovary syndrome. The study will determine which of two medications, Clomiphene Citrate or Letrozole, will most likely result in pregnancy and live birth for women with PCOS.

Participants must: Have PCOS and desire pregnancy

• Have 8 or less periods per year

• Be 18-40 years of age

• Not be taking certain medications

• Have a partner available for intercourse 2-3 times per week for 20 weeks

• Be in general good health Study medication and all study-related visits (including physical exams, blood work and ultrasounds) will be provided at no cost to participants. University of Pennsylvania Penn Fertility Care 3701 Market Street Suite 810 Philadelphia, PA 19104

Obesity and Sperm Counts Obesity is associated with an increase in blood levels of estrogen. Estrogen or “female hormone” is believed to have a negative effect on sperm production. Aromatase inhibitors such as anastrozole work to decrease the production of estrogen and increase testosterone in the body. By decreasing the level of estrogen, sperm production should improve. In this study, the investigators will try to determine the benefit of anastrozole in obese men with low sperm counts. Patients participating in this study will be randomly assigned (by chance) to treatment in one of two study arms: Group A: Anastrozole 1mg per day for 4 months and Group B: Placebo for 4 months. University of Utah Salt Lake City, UT 84132 United States

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