New procedure reveals abnormalities in embryos

lab

A new study has been released showing that 5-day old human blastocysts with an abnormal chromosomal composition can be identified by the rate at which they have developed into a blastocyst, thereby determining the risk of genetic abnormality without a biopsy. The same group which undertook this research has also undertake a retrospective study using their predictive model to assess the likelihood of any embryo transferred resulting in successful pregnancy with encouraging results.

Finding the best candidate for implantation

One of the greatest challenges in any type of assisted reproductive technology is to find a viable egg, sperm or embryo. Having found the egg and sperm to create the embryo, it becomes a guessing game on whether or not that embryo will develop successfully. Considering the expense and emotional toll that ART can level, finding the embryo with the best possible chance is a best case scenario. This new technology uses time lapse imaging of the IVF embryos cultured for 5 days to the blastocyst stage with trophoblast biopsy, the rate of chromosomal abnormality can determined. This approach should allow early and widely accessible non-invasive identification of the best embryo to implant.

Time-lapse imagery may reveal the best embryos

“Recently the world of IVF has become very excited by the use of time-lapse imaging (TLI) of early human embryo development to follow the change of embryo morphology over time,” said Martin Johnson, Editor of Reproductive Biomedicine Online. “The data can then be compared with the outcome after the embryos are transferred. The hope is that this morphokinetic analysis will enable reproductive specialists to predict more successfully those embryos most likely to generate pregnancies. The advantage of using morphokinetic analysis to predict outcome is its minimal invasiveness.”

Identifying chromosomal abnormalities

Chromosomal abnormalities are the leading cause for embryo failure. Until now, it has been impossible to determine the chromosomal integrity without a biopsy of the embryo. “The non-invasive model for the classification of chromosomal abnormality may be used to avoid selecting embryos with high risk of aneuploidy while selecting those with reduced risk,” explained lead author Alison Campbell.

Source: Reproductive BioMedicine Online, MedicalNewsToday


 
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