Hormone injections may reduce infertility

doc with petri

The hormone kisspeptin injected twice daily may provide the key to curing infertility in some women. Findings show that the hormone can lead to the increase of sex hormones which control the menstrual cycle. It’s the first study to show that the effect can be maintained long term. The discovery could lead to new therapies for women who suffer infertility from low sex hormones.

Animals and humans who lack kisspeptin do not experience puberty and remain sexually immature throughout their lives. Dr. Waljit Dhillo of Imperial College London studied women with hypothalamic amenorrhoea, a condition of deficient sex hormone levels which prevents menstruation causing infertility.

There was a previous study led by Dr. Dhillo which showed single doses of kisspeptin had no long term effectiveness. This study sought to find an effective dosage for long term treatment of infertility. It was discovered that twice weekly injections of kisspeptin administered over a two month period successfully stimulated the release of sex hormones in women with infertility due to hypothalamic amenorrhoea and there are no side effects. A larger scale study needs to be done to confirm the success, but these results are very promising.

“The results of our study are exciting as they show that kisspeptin may be a novel method for restoring fertility to women with certain types of infertility. Our findings show that an injection of kisspeptin given twice-weekly can reinvigorate the reproductive hormone system in women and raise their levels of luteinizing hormone and follicle stimulating hormone, both of which are essential for fertility,” said Dr. Dhillo. “It is important to emphasize that this is only a small study and we need to carry out further work before our findings can be brought into clinical practice.”

Source: Society for Endocrinology, ScienceDaily


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