Frozen embryo use with better outcomes than fresh egg IVF


In a new study researchers presented findings announcing that perinatal outcomes using frozen/thawed embryo replacement (FER) have better outcomes compared to fresh in vitro fertilization (IVF) but worse outcomes when compared to the non-IVF general populations. The presentation took place at the Society for Maternal-Fetal Medicine’s annual meeting.

Largest population study on FER and IVF outcomes

The study used a significant amount of data from all IVF treatments in Denmark, Norway and Sweden from1984 through 2007. They cross-linked the data with the Nordic Medical Birth Registries. Babies born from FER were compared to those born after fresh IVF and the general population. Researchers evaluated the data based on eight different criteria: low birth weight, very low birth weight, preterm birth, very preterm birth, small for gestational age, macrosomia (excessive birth weight), large for gestational age, and stillbirth.

FER babies outcome better than IVF, but not spontaneous conception

As compared to the general population spontaneous conceptions, FER babies had a higher rate of preterm birth, very preterm birth, low birth weight, very low birth weight, large for gestational age, and macrosomia. Compared to fresh IVF however, babies born from FER had lower rates of pre-term birth, low birth weight and small gestational age. They had a higher rate of large for gestational age and macrosomia.

FER increasing in use

“FER is used increasingly in IVF programs to avoid the risks associated with multiple births,” said Ulla-Brit Wennerholm, of Sahlgrenska University Hospital in Goteberg, Sweden. “We sought to analyze the outcomes compared to spontaneous conceptions and fresh IVF.”

Outcomes are encouraging

This is the largest population based study of FER. The study confirms previous studies of a worse perinatal outcome as compared with the general population and a better outcome as compared with fresh IVF.

Source: Society for Maternal-Fetal Medicine, MedicalNewsToday


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