Why some embryos do not implant

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Apparently, the secrets to how the uterus performs quality control on new embryos has been discovered. Fertility experts hope the discovery will help develop new techniques to improve the success rate of IVF.

The endometrium is looking for specific enzymes

The research team found that if the endometrium (the lining of the uterus) fails to sense chemical signals from the fertilized egg, it silences the signals from many of the genes involved in allowing it to embed in the uterus. One of the chemical signals the endometrium looks for comes from the enzyme trypsin. The trypsin is given off by the embryo. If trypsin is not given off or otherwise detected by the endometrium, the embryo is not accepted and is left to disintegrate. The cycle begins again.

Implantation is made by a selected embryo

“The lack of trypsin signals appear to indicate to the endometrium that the embryo’s quality is not very high and initiates a reduction in receptivity to implantation,” explained one of the study leaders, Nick Macklon, professor of gynecology and obstetrics at the University of Southampton. The research team came from the UK Universities of Southampton and Warwick, and the University of Utrecht in the Netherlands.

Should improve IVF results

His findings were presented earlier this week at the University of Southampton’s 2013 Institute for Life Sciences Conference. “One in six couples will experience some sort of infertility, which can be both frustrating and daunting, and many will turn to IVF,” said Macklon who is also the director of the Complete Fertility Centre at Southampton. One big problem with IVF is the inability of an embryo to implant. By discovering the importance of trypsin to the endometrium and implantation, these findings should help improve IVF results.

Source: MedicalNewsToday, Society for the Study of Reproduction


 
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