Taking 10-Days of NSAIDS Could Inhibit Fertility in Women

By Mk2010 (Own work) [CC BY-SA 3.0 (http://creativecommons.org/licenses/by-sa/3.0) or GFDL (http://www.gnu.org/copyleft/fdl.html

According to the results of a new study presented at the European League against Rheumatism Annual Congress, diclofenac, naproxen and etoricoxib can significantly inhibit ovulation in women. Of the women who received non-steroidal anti-inflammatory drugs, only 6.3 percent taking diclofenac, 25 percent using naproxen, 27.3 percent receiving etoricoxib ovulated, as compared with 100 percent of the control group.

The Study Findings

The findings of this study suggested that readily available NSAIDs could have a negative effect on fertility, and they should be used sparingly in females who wish to begin a family.

Study investigator Professor Sami Salman, from the Department of Rheumatology, University of Baghdad, Iraq stated, “After just ten days of treatment we saw a significant decrease in progesterone, a hormone essential for ovulation, across all treatment groups, as well as functional cysts on a third of patients.”

Dr. Salman further said, “These findings show that even short-term use of these popular, over-the-counter drugs could have a significant impact on a woman’s ability to have children. This needs to be better communicated to patients with rheumatic diseases, who may take these drugs on a regular basis with little awareness of the impact.”

NSAIDs are some of the most commonly used drugs in the world, and taken by millions of people every single day. These medications are available without a prescription and used for pain management, inflammation and fever, which are all typical features of rheumatic diseases.

Thirty-nine females of childbearing age who suffered from back pain took part in the study. The women received either diclofenac 100 mg once per day, naproxen 500 mg two times per day, etoricoxib 90 mg one time per day or a placebo. Treatment was provided for 10 days from day ten, at the beginning of the menstrual cycle.

The researchers did a hormonal analysis and follicle diameter test and found that at the end of NSAID treatment, 75 percent of women had an unruptured dominant follicle. Rupture of the dominant follicle is necessary, in order for an oocyte to be released and ovulation to occur.

Conclusion of the Study:

The findings of the study highlight the dangers and harmful effects of non-steroidal anti-inflammatory drugs could have on fertility. In order for researchers to have a better understanding of how NSAIDs can threaten a female’s fertility, more study is needed. There is a definite need for medical science to come up with new medications and treatment options for pain management, particularly in women of child bearing age.


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