Nasty BPA makes headlines again

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A new article in the Journal of Clinical Endocrinology & Metabolism reveals research that has found higher Bisphenol A (BPA) levels in women with polycystic syndrome (PCOS) than in the control group. Researchers also found a statistically important association between male sex hormones and BPA in these same women suggesting a potential role of BPA in ovarian dysfunction. BPA just has its nastiness all over the place.

If you hadn’t heard, BPA is a very common industrial compound used in food and drink convenience packaging (many plastics) and many other things you wouldn’t suspect, like dental implants. PCOS is a common endocrine disorder and is notable for its excessive secretion of androgens which are masculinization hormones. It is a very common source of obesity, type 2 diabetes, heart disease and infertility for women of childbearing years.

“Our research shows that BPA may be more harmful to women with hormonal and fertility imbalances like those found in PCOS,” said Evanthia Diamanti-Kandarakis, MD, Phd, study co-author and professor at the University of Athens Medical School in Greece. “These women should be alert to the potential risks and take care of themselves by avoiding excessive every-day consumption of food or drink from plastic containers.”

We could all heed that advice. “Excessive secretion of androgens, as seen in PCOS, interfere with BPA detoxification by the liver, leading to accumulation of blood levels of BPA,” said Diamanti-Kandarakis. “BPA also affects androgen metabolism, crating a vicious circle between androgens and BPA.”

Source: The Endocrine Society, ScienceDaily


 
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