Woman 1st giving birth twice with ovary transplant

Stinne Holm Bergholdt of Denmark was diagnosed with bone cancer at age 27, and she was afraid she wouldn't be able to have children.
Mrs. Stinne Holm Bergholdt of Odense, Denmark, gave birth in 2007 after fertility treatment and again in 2008, her doctor reported in the Feb. 25 online issue of the journal Human Reproduction. Both children are girls. Before undergoing toxic cancer treatments, doctors retrieved part of her right ovary and preserved it by freezing. Her left ovary had been removed previously because of a cyst.
Her treatment included multiple sessions of chemotherapy and then surgical removal of the rest of the tumor. The chemo put her into early menopause.
In December 2005, doctors transplanted six thin strips of ovarian tissue from what remained of her right ovary and it began working again. She underwent mild ovarian stimulation and became pregnant, giving birth to her first daughter Aviaja in February 2007. She went back to the fertility doctor last year to begin ovarian stimulation again, only to find she was already pregnant.

"This is the first time in the world that a woman has had two children from separate pregnancies as a result of transplanting frozen/thawed ovarian tissue," her doctor, Claus Yding Andersen, professor in human reproductive physiology at the University Hospital of Copenhagen, said in a news release from the journal's publisher. "These results support cryopreservation of ovarian tissue as a valid method of fertility preservation and should encourage the development of this technique as a clinical procedure for girls and young women facing treatment that could damage their ovaries."
In an interview for WebMd, the doctor explained, ''We performed IVF [in vitro fertilization] initially, and expected to do that for the second child also," says Andersen. ''However, this wasn't necessary and it turns out that maybe we do not need to do assisted reproduction in many of the cases.