BRCA 1/2 Negative But May Still Be Genetically At Risk For Ovarian Cancer

Gynos are still struggling to detect early stage ovarian cancer. The best we've come up with so far is to eliminate risk in those that genetically are at the highest risk. Women with BRCA 1 have about a 50% risk by age 50 and those with BRCA 2 have about an 85% lifetime risk of ovarian cancer. Ovarian removal in these women can reduce these risks down to extremely low rates. We now think that there is another genetic variant that helps explain the families of women who have risk but test negative for BRCA 1 and 2. This is the new test called PrOvar. It's very new, it's not widely available, and it's in the development phase.Remember, that pelvic examinations, close attention to how you feel, and in some cases pelvic ultrasounds, and when indicated, 3-D imaging will help identify women who already have disease. Once you have disease, Ova1 testing may be indicated to get proper treatment.


The information provided on is designed to support, not replace, the relationship that exists between a patient/site visitor and his/her health professional. This information is solely for informational and educational purposes. The publication of this information does not constitute the practice of medicine, and this information does not replace the advice of your physician or other health care provider. Neither the owners or employees of nor the author(s) of site content take responsibility for any possible consequences from any treatment, procedure, exercise, dietary modification, action or application of medication which results from reading this site. Always speak with your primary health care provider before engaging in any form of self treatment. See our Legal Statement for more details.

Fertility Clinics Directory

Find a Fertility Clinic

If you or a loved one is suffering from infertility and needs help conceiving then we are here to offer help in any way we can. We have over 450 Fertility Clinics listed on our Directory. Click here to search for a Fertility Clinic that is right for you.