PCOS and diabetes

young women walk away

A recent study published in The Endocrine Society’s Journal of Clinical Endocrinology & Metabolism revealed that early intervention with a diabetes drug called metformin may prevent or delay polycystic ovary syndrome (PCOS) in young women.

PCOS is the leading cause of infertility affecting close to ten percent of women who have trouble conceiving. That’s 5 to 6 million women in the United States alone.

“PCOS often presents in adolescence, with irregular menstrual cycles, acne, or too much body hair,” said Lourdes Ibanez, professor of pediatrics at the University of Barcelona. “But we believe the critical years for PCOS development may be during childhood and puberty when excessive amounts of fat are stored. That excessive weight gain overexposes the o varies to insulin, causing them to stop ovulating and start releasing male hormones, resulting in PCOS.”

For this study, researchers examined 38 girls with low birth-weight and early puberty. They administered early and late metformin treatment and compared the effectiveness of both approaches. The study ran for six years comparing girls who were on the drub for that entire time and girls who started for the final year of the project. Ibanez and her team found that the early intervention group showed fewer symptoms of PCOS.

“Metformin, when given across the potentially critical window of puberty, may have the capacity to reprogram metabolism toward less abdominal and liver fat,” she concluded. “In the years ahead, the focus of attention should shift from late treatment of PCOS and its complications, toward the early and large-scale prevention of PCOS, with measures such as diet, exercise ad metformin in young girls.”

Source: The Endocrine Society (JCEM), Science Daily


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