Aspirin for pregnancy after miscarriage

pink belly

A daily dose of aspirin increases the chance of conceiving and having a live birth in women who have suffered a single recent pregnancy loss.

New evidence for a common practice

Based on anecdotal success, many doctors have prescribed low dose aspirin to women who have suffered a miscarriage or stillbirth and want to conceive again. There has been no evidence to support the practice.

Double blind study of more than 1000 women

Dr. Enrique Schistman of the Eunice Kennedy Shriver national Institute of Child Health and Human Development, randomly assigned more than 1000 women with a history of miscarriage or stillbirth to one of two groups: the aspirin group and the placebo group. The aspirin group took a daily dose of 81mg aspirin and folic acid. The placebo women took a dummy pill and folic acid. The women were between 18 and 40. They followed for six months while they tried to get pregnant and for through the pregnancy if they did conceive. The pregnant women taking aspirin did so until 36 weeks of gestation.

Not significant for pregnancy loss prevention

At the end of the study, 58% of the women who took aspirin became pregnant and later gave birth while 53% of placebo women experienced the same. 13% of the aspirin group experienced another pregnancy loss compared to 2% of the placebo group. There was no significant difference in pregnancy loss rates between the groups.

Could be helpful for subsequent pregnancy and birth

A subgroup of women who had experienced a single, recent miscarriage had a higher rate of pregnancy and live birth while taking the low dose aspirin. 78% of women on aspirin and 66% on placebo conceived while 62% on aspirin and 53% on placebo had a live birth. The reason is not known. It may be that aspirin helps increase the flow of blood to the uterus which better supports the pregnancy.

Source: MedicalNewsToday, The Lancet


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